Isocitrate dehydrogenase [NADP] cytoplasmic

IDH1 (isocitrate dehydrogenase [NADP] cytoplasmic) catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate to 2-ketoglutarate and plays a critical role in generating NADPH, an essential cofactor for biosynthesis pathways (UniProt: O75874). The protein is located in the cytoplasm and may also function as a corneal epithelial crystallin.

IDH1 is associated with glioma in the UniProt disease database (UniProt: O75874). The protein's role in cellular redox metabolism and energy production positions it within broader metabolic and antioxidant defense pathways relevant to neurological tissues.

IDH1 is tagged as upregulated in Alzheimer's Disease (Chaparral AD proteomics). In post-mortem AD brain tissue compared to age-matched controls, IDH1 showed increased abundance with a mean log2 fold-change of 0.61 across subcellular fractions, suggesting enhanced metabolic activity or compensatory oxidative stress response in AD pathology.