DnaJ homolog subfamily A member 2

DNAJA2 (DnaJ homolog subfamily A member 2) is a 45.7 kDa co-chaperone protein that functions as a regulator of heat shock protein Hsc70 (UniProt: O60884). It stimulates ATP hydrolysis and facilitates the folding of unfolded proteins in cooperation with HSPA1A/B, playing a central role in cellular protein quality control mechanisms.

DNAJA2 is broadly expressed and participates in the heat shock protein chaperone network, which is critical for proteostasis across multiple tissues including the central nervous system. No specific disease associations are documented in UniProt for this protein.

In Alzheimer's disease, DNAJA2 shows ambiguous regulation across subcellular fractions from post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). Analysis by TMT-labeled quantitative proteomics across four subcellular compartments (P2, P3, S2, S3) detected the protein in 2 of 4 fractions with a mean log2 fold-change of 0.136, indicating minimal overall expression change but inconsistent direction across fractions. This pattern suggests context-dependent or compartment-specific alterations in DNAJA2 levels in AD pathology.