Leucine zipper putative tumor suppressor 3

LZTS3 (Leucine zipper putative tumor suppressor 3) is a 673-amino-acid protein encoded by the LZTS3 gene. It may promote the maturation of dendritic spines by regulating SIPA1L1 levels at the postsynaptic density, suggesting a role in synaptic organization and plasticity (UniProt: O60299).

The protein functions primarily in synaptic compartments, where it contributes to postsynaptic structure and function. No disease associations are listed in the UniProt record.

LZTS3 shows decreased abundance in Alzheimer's disease brain tissue. Analysis of human post-mortem AD brain relative to age-matched controls using TMT-labeled quantitative proteomics across four subcellular fractions (P2, P3, S2, S3) revealed a mean log2 fold-change of −0.53, indicating downregulation in AD (Chaparral AD proteomics). This reduction may reflect compromised synaptic integrity characteristic of neurodegeneration in Alzheimer's disease.