PDZ and LIM domain protein 1

PDZ and LIM domain protein 1 (PDLIM1) is a cytoskeletal adapter protein that facilitates the assembly and organization of stress fibers in cells (UniProt: O00151). It functions by bringing other proteins, including kinases, to the cytoskeleton and is required for proper localization of actin-associated proteins like ACTN1 and PALLD. The protein also plays a role in cell migration and maintaining fibroblast polarity.

PDLIM1 is expressed in human tissues where cytoskeletal dynamics are important, particularly in cells undergoing migration and morphological changes (UniProt: O00151). No inherent genetic disease associations are documented in UniProt for this protein.

In Alzheimer's disease, PDLIM1 shows increased abundance in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of 1.13 (Chaparral AD proteomics). This upregulation was detected across subcellular fractions in a TMT-labeled quantitative proteomics study, suggesting potential involvement in AD-related cytoskeletal reorganization or cellular stress responses in affected brain tissue.